Eugene married Olivia Jane McCullough 29 Jun 1875, Hyde Park, , Massachusetts, United States. Olivia (daughter of John McCullough and Mary Jane Oulton) was born 1 Aug 1849, Amherst, Cumberland, Nova Scotia, Canada; died 5 Sep 1909, Boston, Suffolk, Massachusetts, United States; was buried , Forest Hills Cemetery, Boston, , Massachusetts, United States. [Group Sheet]

1. Grace Olivia Sanford was born May 1876, Hyde Park, , Massachusetts, United States; died 2 Jun 1943.
2. Arthur Eugene Sanford was born 21 Nov 1879, Hyde Park, , Massachusetts, United States; died Yes, date unknown.
3. Chester Oulton Sanford was born 28 Jul 1885, Hyde Park, , Massachusetts, United States; died Yes, date unknown.